The innate immune system provides the first line of defense against both infections and cancers. Dysregulated innate immunity, sometimes related to chronic infections, can underlie neoplastic, autoimmune and neurodegenerative diseases. Many immune cell types (neutrophils, macrophages, NK & T cells, epithelial and endothelial cells) deploy and/or are modulated by innate immune effectors, e.g. host defense peptides. From the primary literature, we discuss the breadth, structures, and functions of cellular and molecular innate immune effectors, their relation to disease, and how bioengineering these systems can benefit human health. Appropriate for grads and undergrads with knowledge of biochemistry, molecular/cell biology, biophysics, and/or bioengineering.
3 units · Letter or Credit/No Credit
The innate immune system provides the first line of defense against both infections and cancers. Dysregulated innate immunity, sometimes related to chronic infections, can underlie neoplastic, autoimmune and neurodegenerative diseases. Many immune cell types (neutrophils, macrophages, NK & T cells, epithelial and endothelial cells) deploy and/or are modulated by innate immune effectors, e.g. host defense peptides. From the primary literature, we discuss the breadth, structures, and functions of cellular and molecular innate immune effectors, their relation to disease, and how bioengineering these systems can benefit human health. Appropriate for grads and undergrads with knowledge of biochemistry, molecular/cell biology, biophysics, and/or bioengineering.